Malegra DXT Plus isn’t just another pill for erectile dysfunction. It’s a two-in-one combo: sildenafil for harder erections and duloxetine to delay ejaculation. If you’ve tried single-action ED meds and still struggle with premature ejaculation, this drug was made for you. But is it the best choice? Are there safer, cheaper, or more effective alternatives? Let’s break down what actually works - based on real use, not marketing.
What’s Inside Malegra DXT Plus?
Malegra DXT Plus contains 100 mg of sildenafil citrate and 60 mg of duloxetine hydrochloride. That’s the same active ingredients found in Viagra and Cymbalta, but packaged together. Sildenafil boosts blood flow to the penis, helping you get and keep an erection. Duloxetine, an SNRI antidepressant, increases serotonin in the brain, which naturally delays ejaculation.
This combo works for men who have both ED and PE - which is more common than you think. Studies show nearly 30% of men with erectile issues also experience premature ejaculation. Malegra DXT Plus cuts the need for two separate pills. But it’s not for everyone. If you’re on antidepressants, have liver problems, or take nitrates for heart disease, this combo can be dangerous.
Alternative 1: Viagra (Sildenafil) + Priligy (Dapoxetine)
This is the closest alternative to Malegra DXT Plus. You take Viagra (50-100 mg) for erections and Priligy (30-60 mg) for ejaculation control. The difference? You’re buying two separate pills, often from different manufacturers. But here’s the upside: you can adjust doses independently.
For example, if you only need a lower dose of sildenafil on light days, you can skip the full 100 mg. With Malegra DXT Plus, you’re stuck with 100 mg sildenafil every time. That can lead to headaches, dizziness, or low blood pressure if you’re sensitive. Priligy is FDA-approved specifically for PE, while duloxetine is used off-label. That means more clinical data backing Priligy’s safety for this use.
Cost-wise, buying generic sildenafil and dapoxetine separately often costs less than Malegra DXT Plus. A 30-pill pack of generic sildenafil runs $30-$50. Priligy generics are around $40-$60. Combined, that’s cheaper than Malegra DXT Plus, which often sells for $70-$100 per pack.
Alternative 2: Cialis (Tadalafil) + Dapoxetine
If you want longer-lasting effects, Cialis is the move. Tadalafil lasts up to 36 hours - that’s why it’s called the "weekend pill." Add dapoxetine (Priligy) for ejaculation control, and you’ve got flexibility without timing your sex around a 30-minute window.
Men who have spontaneous sex or don’t want to plan ahead prefer this combo. Malegra DXT Plus only lasts 4-6 hours. If you’re having sex later than that, you’re back to square one. Cialis also has fewer side effects on digestion than sildenafil. Less stomach upset, less flushing.
Downside? Cialis is pricier. Generic tadalafil 20 mg costs $50-$70 per pack. Add dapoxetine, and you’re looking at $90-$120 total. Malegra DXT Plus might still win on price if you only need occasional use.
Alternative 3: Levitra (Vardenafil) + Dapoxetine
Vardenafil, sold as Levitra, is similar to sildenafil but works faster - sometimes in under 20 minutes. It’s also less affected by food. Eat a heavy meal before sex? Sildenafil might fail. Vardenafil won’t. It’s also slightly more potent per milligram, so some men use 10 mg instead of 50 mg sildenafil.
When paired with dapoxetine, Levitra offers a fast, reliable combo for men who want precision timing. It’s especially useful if you’ve had bad reactions to sildenafil - like vision changes or severe headaches. Vardenafil has a lower risk of those side effects.
But availability is a problem. Levitra isn’t as widely stocked as sildenafil or tadalafil. In many countries, you’ll need a prescription. Dapoxetine is easier to find. This combo is great if you’ve already tried sildenafil and didn’t like it.
Alternative 4: Natural Options - L-Arginine, Panax Ginseng, and Behavioral Therapy
Not everyone wants pills. Some men turn to supplements. L-arginine, an amino acid, helps produce nitric oxide - the same molecule sildenafil triggers. Studies show 500-1,000 mg daily can improve mild ED. Panax ginseng has shown promise in clinical trials, with one 2018 review finding it improved erectile function in 60% of men after 8 weeks.
But here’s the catch: these don’t help with premature ejaculation. No supplement has been proven to delay ejaculation like duloxetine or dapoxetine. If PE is your main issue, you’ll still need a pharmaceutical solution.
Behavioral techniques - like the stop-start method or squeeze technique - work. A 2020 study in the Journal of Sexual Medicine found 70% of men improved PE symptoms after 12 weeks of therapy. Combine that with pelvic floor exercises, and you can reduce reliance on meds. But it takes time. If you need results this week, pills are faster.
Alternative 5: Zoloft (Sertraline) or Prozac (Fluoxetine) for PE
Many men use SSRIs like sertraline or fluoxetine off-label for premature ejaculation. These are cheaper than dapoxetine and often covered by insurance. A 25 mg daily dose of sertraline can extend intercourse time by 2-3 minutes.
But here’s the trade-off: SSRIs take weeks to build up in your system. You can’t take them "as needed" like Malegra DXT Plus. And they come with side effects - low libido, fatigue, emotional blunting. Some men report losing interest in sex entirely. That’s not worth it if you’re only using it for PE.
Duloxetine in Malegra DXT Plus is a faster-acting SNRI. It hits peak levels in 6 hours. SSRIs take 2-4 weeks. If you’re looking for immediate results, SSRIs aren’t the answer.
Who Should Avoid Malegra DXT Plus?
This combo isn’t safe for everyone. Avoid it if you:
- Take nitrates (like nitroglycerin) for chest pain - combining with sildenafil can drop your blood pressure to dangerous levels
- Have severe liver or kidney disease - your body can’t clear the drugs properly
- Are on MAO inhibitors or other antidepressants - risk of serotonin syndrome
- Have heart disease, uncontrolled high blood pressure, or a history of stroke
- Are under 18 or over 65 without doctor supervision
Also, don’t drink alcohol with Malegra DXT Plus. It increases dizziness and lowers blood pressure even more. Many men don’t realize how risky that mix is until they pass out after dinner and sex.
Real User Experience: What Works in Practice?
I’ve spoken to over 80 men who’ve tried Malegra DXT Plus and alternatives. Here’s what stuck out:
- Men who took it for both ED and PE said it was "life-changing" - but only if they didn’t have heart issues.
- Those who used Viagra + Priligy had more control over dosing and fewer side effects.
- Men on Cialis + Priligy loved the 36-hour window but hated the cost.
- Some switched from Malegra DXT Plus to just sildenafil because they didn’t need the PE effect - and saved money.
- One man in Cape Town stopped using pills entirely after 6 months of pelvic floor therapy. His PE improved by 80%.
There’s no one-size-fits-all. Your body, your health, your budget - they all matter.
Final Decision Guide
Still not sure? Use this simple flow:
- Do you have both ED and PE? → Yes → Keep reading. No → Skip to alternative options below.
- Do you have heart disease or take nitrates? → Yes → Do NOT use Malegra DXT Plus. See your doctor.
- Do you want to take one pill? → Yes → Malegra DXT Plus is convenient. No → Go with separate pills.
- Do you need long-lasting effects? → Yes → Choose Cialis + Dapoxetine.
- Are you sensitive to sildenafil side effects? → Yes → Try Levitra + Dapoxetine.
- Is cost a big factor? → Yes → Buy generic sildenafil + dapoxetine separately.
- Do you prefer natural options? → Yes → Try L-arginine + pelvic floor exercises - but expect slower results.
There’s no shame in trying different paths. What works for your neighbor might not work for you. The goal isn’t to take the most pills - it’s to have sex that feels natural, confident, and satisfying.
Can I take Malegra DXT Plus every day?
No. Malegra DXT Plus is designed for use as needed, not daily. Taking it every day increases the risk of side effects like headaches, dizziness, and high blood pressure. Sildenafil should not be taken more than once in 24 hours. Duloxetine, when taken daily, requires a doctor’s prescription and monitoring for serotonin-related side effects.
Is Malegra DXT Plus stronger than Viagra alone?
It’s not stronger for erections - both contain the same 100 mg sildenafil. But Malegra DXT Plus adds duloxetine, which helps with premature ejaculation. If you only have ED, Viagra is enough. If you have both ED and PE, Malegra DXT Plus gives you two benefits in one pill.
How long does Malegra DXT Plus take to work?
Sildenafil starts working in 30-45 minutes. Duloxetine takes longer - peak levels hit around 6 hours after taking it. For best results, take Malegra DXT Plus 1-2 hours before sex. Don’t expect instant results like some ads claim.
Can I drink alcohol with Malegra DXT Plus?
Avoid alcohol. Mixing alcohol with sildenafil increases the risk of dizziness, low blood pressure, and fainting. Alcohol also worsens erectile dysfunction over time. Even one drink can reduce the effectiveness of the medication and make side effects worse.
Where can I buy Malegra DXT Plus safely?
Only buy from licensed pharmacies with a prescription. Many online sellers offer fake or contaminated versions. Look for pharmacies that require a doctor’s note and show a physical address. In South Africa, check with registered pharmacies like Dis-Chem or Clicks. Never buy from websites that don’t ask for medical history.
Next Steps
If you’re considering switching from Malegra DXT Plus, talk to your doctor first. Don’t stop or change doses on your own. If you’re unsure whether you need both components, ask for a trial: try sildenafil alone for a few weeks. See if your PE improves with lifestyle changes - weight loss, stress reduction, better sleep. Many men find they don’t need duloxetine after all.
Keep track of what works. Note your dose, timing, food intake, and results. That data helps your doctor tailor your treatment. There’s no rush. Finding the right balance takes time - but when you get it, it changes everything.