If you’ve been told you have functional dyspepsia, you might have heard of acotiamide. It’s a medicine that boosts stomach movement, helping food pass through more smoothly. Think of it as a little push for your gut when it’s feeling sluggish.
Acotiamide is sold under brand names like SAPRAY and is approved in several countries for treating functional dyspepsia with prominent early satiety. It targets a specific chemical called acetylcholinesterase, keeping more acetylcholine around to stimulate gastric muscles. The result is less bloating, less fullness after small meals, and a calmer stomach overall.
The typical adult dose is 100 mg three times a day, taken before meals. You’ll want to swallow the tablets whole with a glass of water; don’t crush or chew them. If you miss a dose, take it as soon as you remember, but if it’s close to your next scheduled dose, just skip the missed one—don’t double up.
Doctors may adjust the dose for older patients or those with liver problems, but most people stick with the standard schedule. Always follow your doctor’s instructions and keep a medication list handy in case you need to tell another health professional.
Acotiamide is generally well tolerated, but a few users report mild stomach pain, diarrhea, or a dry mouth. These usually fade after a few days. Rarely, people notice a headache or dizziness. If any reaction feels severe—like intense abdominal cramps or allergic swelling—stop the drug and call your doctor right away.
Because acotiamide works on gut movement, it isn’t a good fit for people with severe gastrointestinal obstruction, ulcer perforation, or certain heart conditions. Tell your doctor about any other meds you’re taking, especially other drugs that affect acetylcholine, like some antidepressants or anticholinergics.
Pregnant or breastfeeding moms should discuss risks with their doctor. The data is limited, so it’s usually only prescribed when the benefits clearly outweigh potential risks.
Storing acotiamide is easy—keep it in the original bottle, away from heat and moisture, and out of reach of children. If a tablet looks broken or discolored, don’t use it; get a fresh supply.
In summary, acotiamide can be a useful tool for easing functional dyspepsia symptoms. Stick to the prescribed dose, watch for any side effects, and keep an open line with your healthcare provider. With the right approach, many people find their stomach feels less trapped and more normal after meals.